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For those who aren't up to speed, Retatrutide is being hailed as a first-of-its-class Retatrutide triple agonist. Instead of just targeting GLP-1 (like Semaglutide) or GLP-1/GIP (like Tirzepatide), it hits three receptors: GLP-1, GIP, and glucagon. This unique synergy appears to be driving significantly higher metabolic rates and energy expenditure, not just appetite suppression.
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Specifically, I’m curious about Retatrutide for obesity in patients who don't have type 2 diabetes. Since it acts on the glucagon pathway, does it increase heart rate too much for non-diabetics? Or is the weight loss benefit worth the potential sides?
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Would love to hear thoughts from anyone currently researching this or considering the switch. Has anyone seen data on the maintenance phase after stopping? Let’s discuss below.
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